Fine-tuning and testing a multilingual large language model is a challenge for low-resource languages (LRLs) since it is an expensive process. While previous studies have predicted the performance of natural language processing (NLP) tasks using machine learning methods, they primarily focus on high-resource languages, overlooking LRLs and shifts across domains. Focusing on LRLs, we investigate three factors (the size of the fine-tuning corpus, domain similarity between fine-tuning and testing corpora, and language similarity between source and target languages), which can potentially impact the model performance by using classical regression models. Our results indicate that domain similarity has the most important impact on predicting the performance of Machine Translation models.